Tag: Lonnie Shea
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Synthetic Immunological Niches Could Offer an Earlier Warning of Islet Transplant Rejection
Research from the Shea Lab uses implantable synthetic immunological niches to monitor immune activity, with the goal of identifying islet transplant rejection before conventional clinical measures can.
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Nanoparticles Can Prevent Scars and Spark Nerve Regeneration in Spinal Cord Injuries
By deploying targeted therapeutic nanoparticles, the research team has successfully reprogrammed immune cells at the injury—not just halting damage, but actively driving a pro-regenerative response that prevented scar formation and stimulated nerve regrowth.
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U-M BME Researchers Develop Nanoparticle Therapy to Boost the Immune System’s Attack on Metastatic Cancer
This innovation could mark a major turning point in how metastatic cancers are treated in the future.
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U-M Researchers Collaborate to Identify New Therapeutics in Models of Progressive Multiple Sclerosis
Dr. Morris and his team are working to devise a more effective treatment by delving deeper into the disease’s cellular mechanisms.
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Lonnie Shea Receives Stephen S. Attwood Award
The Stephen S. Attwood Award is one of the highest honors bestowed by the CoE.
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Tick-borne red meat allergy prevented in mice through new nanoparticle treatment
Lonnie Shea, the Steven A. Goldstein Collegiate Professor of Biomedical Engineering at the University of Michigan, along with other researchers at U-M and the University of Virginia, is studying how nanoparticles containing small amounts of allergen can prevent allergic reactions to food in mice.
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Nanoparticles reprogram mouse immune systems to cope with allergens
Treatment suppressed anaphylaxis and reduced gut inflammation after just two intravenous infusions.
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U-M BME Researchers Use Scaffolding Sensors to Detect Early Evidence of Organ Transplant Rejections
To identify rejection prior to graft injury, the U-M BME team used a microporous scaffold that functions as a minimally-invasive surveillance method
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U-M BME Researchers Develop Technique to Enhance Neurorepair in Spinal Cord Injuries
This study, published in Nature Regenerative Medicine, highlights regeneration in the injured spinal cord, which traditionally is limited by physical and chemical barriers.
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U-M BME-led study reveals the key role of anti-tumor neutrophils in suppressing lung metastasis of breast cancer
The research team employed a subcutaneous biomaterial scaffold implant