Alison Vander Roest, Ph.D.

Assistant Professor, Biomedical Engineering


Lurie Biomedical Engineering
1101 Beal Ave
Ann Arbor, MI 48109-2110

Primary Website

Cardiac Mechanobiology Lab

Research Interests

My research interests are in the field of cardiac mechanobiology, seeking to understand how the mechanical environment in the heart influences cell behavior and cardiac function throughout pediatric development and disease. My lab will use gene edited human stem-cell derived in vitro systems, and computational models to study disease and potential therapeutics to improve precision medicine.

Research Areas:

Biomechanics, Biomedical Computation and Modeling, Cardiovascular, Molecular and Cellular Biomechanics, Tissue Engineering and Biomaterials, Tissue Engineering and Regenerative Medicine


Dr. Vander Roest is originally from Texas and received degrees in Biomedical Engineering from the University of Virginia and Vanderbilt University. Her postdoctoral work at Stanford University focused on using gene edited stem-cell derived cardiomyocytes in micropatterned environments to measure the impact of disease-causing mutations. Her K99/R00 funded project will continue in her independent work using multiscale computational modeling approaches to relate cardiac mechanics from the molecular to the cellular/multicellular scale and study the impact of cardiac fibrosis.