William Stacey, M.D., Ph.D.

Professor, Neurology

Office Location

NCRC, B10-A187
2800 Plymouth Rd
Ann Arbor, MI 48109-2800


(734) 936-7310

Research Interests

Dr. Stacey’s lab is dedicated to developing better engineering tools to control epilepsy and is an active participant in the Translational Neural Engineering Group. Dr. Stacey is a clinical epilepsy specialist and spends the majority of his time doing neural engineering research. The lab uses a combination of electrophysiology, machine learning, signal processing, and computational modeling. Data for these projects are acquired from a large database of human patients, an ongoing analysis of frequent epilepsy patients, and rodent models of epilepsy. The lab is specifically researching the relationship of high-frequency oscillations with seizure mechanisms, and developing methods to target and stimulate the brain to stop seizures. Concurrently, the lab has an ongoing international collaboration to develop biophysical and dynamical models of epileptic activity to understand the mechanisms underlying seizures and epileptic oscillations.

We are accepting new PhD students in 2024.

Lab Location:
NCRC, B14-190
2800 Plymouth Rd
Ann Arbor, MI 48109-2800

Research Areas:

Biomedical Computation and Modeling, Neural Engineering

Additional Title(s)

Professor, Biomedical Engineering

Selected Publications by Subject

Computational and Dynamical Modeling

  • Fink, C.G., Gliske, S., Catoni, N., and Stacey, W.C. Network Mechanisms Generating Abnormal and Normal Hippocampal High-Frequency Oscillations: A Computational Analysis. Eneuro. 2015;2(3).
  • Saggio ML, Crisp D, Scott JM, Karoly P, Kuhlmann L, Nakatani M, Murai T, Dumpelmann M, Schulze-Bonhage A, Ikeda A, Cook M, Gliske SV, Lin J, Bernard C, Jirsa V, Stacey WC. A taxonomy of seizure dynamotypes. Elife. 2020;9.
  • Szuromi MP, Jirsa VK, Stacey WC. Optimization of ictal aborting stimulation using the dynamotype taxonomy. J Computational Neuroscience. 2023. 

In vitro Electrophysiology

  • Luna-Munguia H, Starski P, Chen W, Gliske SV, Stacey WC.  Control of in vivo ictogenesis via endogenous synaptic pathways.  Sci Reports. 2017.7(1):1311.
  • Crisp DN, Cheung W, Gliske SV, Lai A, Freestone DR, Grayden DB, Cook MJ, Stacey WC. Quantifying epileptogenesis in rats with spontaneous and responsive brain state dynamics. Brain Commun. 2020;2(1):fcaa048.

Human Epilepsy

  • Stacey, W.C., and Litt, B. Technology Insight: neuroengineering and epilepsy—designing devices for seizure control. Nat Clin Prac Neurol. 4:190-201, 2008.  (Review)
  • Jirsa, V., Stacey, W.C., Quilichini, P. P., Ivanov, A. I., and Bernard, C..  On the Nature of Seizure Dynamics  Brain 137:2210-30, 2014.

Data Science

  • Gliske SV, Irwin ZT, Chestek C, Hegeman GL, Brinkmann B, Sagher O, Garton HJL, Worrell GA, Stacey WC. Variability in the location of high frequency oscillations during prolonged intracranial EEG recordings. Nat Commun. 2018;9(1):2155.
  • Scott JM, Ren S, Gliske SV, Stacey WC. Preictal variability of high-frequency oscillation rates in refractory epilepsy. Epilepsia. 2020. Epub 2020/09/19

Professional Credentials

  • Medical School , Case Western Reserve University School of Medicine, 2002
  • Residency
  • University Hospitals – Case Medical Center, Neurology, OH, 2006
  • Fellowship, Epilepsy, University of Pennsylvania Hospital, 2008
  • Board Certification, Neurology, Epilepsy