Location
NCRC, Bldg 28, Room 3048W
2800 Plymouth Rd
Ann Arbor, MI 48109-0028
Phone
(734) 764-9889
Primary Website
Research Interests
Research Areas:
Biomedical Computation and Modeling, Tissue Engineering and Biomaterials, Tissue Engineering and Regenerative Medicine
Biography
Dr. Nagrath’s lab is focused on answering the question-What is the role of tumor microenvironment in modulating cancer cell metabolism? Nagrath lab has developed several metabolic isotope tracing and 13C-based metabolic flux analysis techniques. Recently, the lab developed a metabolic systems biology approach, collateral lethal genes identification via metabolic fluxes (CLIM) to integrate genomic and transcriptomic data with machine learning and genome-scale metabolic flux analysis in ovarian cancer. Notably, the lab is focused on personalized metabolic therapy and circulating tumor cell organoids and tumor tissue slices in pancreatic, lung, and breast cancers. With extensive expertise in machine learning, metabolic flux analysis and systems metabolomics, the lab is building new quantitative models to measure flux in brain cancers and their microenvironment.