Shoe-box size breath-analyzer spots deadly lung disease faster, more accurately than doctors The device could also be used to detect other diseases such as pneumonia, sepsis, asthma and others associated with lung or systemic blood inflammation.
August 1, 2019
A small, portable breath monitor developed at the University of Michigan can quickly and accurately detect acute respiratory distress syndrome (ARDS), an often deadly disease that causes fluid to leak into the lungs and demands early diagnosis. To detect the condition today, doctors rely heavily on their own judgement, and time-consuming tests. The researchers say […]Read more »
Injectable ‘bone spackling’: A cell therapy approach to heal complex fractures A Q&A with biomedical engineering professor Jan Stegemann, whose work in mice shows the promise of ‘microtissues.’
August 1, 2019
Large, complex bone wounds are hard for doctors and patients alike to contend with. They often require grafts and multiple surgeries. Jan Stegemann, a University of Michigan professor of biomedical engineering, is reprogramming adult cells from bone marrow so that they can be injected directly into a wound and grow into bone. The marrow-derived cells […]Read more »
Overuse, or one bad move? New view on ACL tears prompt questions on how athletes train New research suggests a reevaluation of the way athletes train and prepare for competition.
July 29, 2019
Tears of the knee’s anterior cruciate ligament (ACL), a serious injury for athletes, may not just be the result of one instant of giving the joint more than it can handle, but rather the cumulative effect of less-severe, repeated stresses. It’s a finding from University of Michigan researchers that could have implications for athletes of […]Read more »
An EpiPen for spinal cord injuries U-M researchers have designed nanoparticles that intercept immune cells on their way to the spinal cord and redirect them away from the injury.
July 9, 2019
An injection of nanoparticles can prevent the body’s immune system from overreacting to trauma, potentially preventing some spinal cord injuries from resulting in paralysis. The approach was demonstrated in mice at the University of Michigan, with the nanoparticles enhancing healing by reprogramming the aggressive immune cells. Call it an EpiPen for trauma to the central […]Read more »
By Cannibalizing Nearby Stromal Stem Cells, Some Breast Cancer Cells Gain Invasion Advantage Cancer biologists and engineers collaborated on a device that could help predict the likelihood of breast cancer metastasis.
July 8, 2019
Researchers at the University of Michigan Rogel Cancer Center and U-M College of Engineering have found that breast cancer cells that swallow up nearby stem cells take on some of their properties, enhancing their ability to invade other tissues throughout the body and seed secondary tumors, a process known as metastasis. It started with an unexpected observation […]Read more »
July 5, 2019
About 300,000 individuals in the United States alone are living with a spinal cord injury, based on data gathered by the National Spinal Cord Injury Statistical Center, with nearly 18,000 new cases occurring each year. The injuries can be devastating, having a major impact on daily life, including on bowel and bladder control, the ability […]Read more »
Kirigami can spin terahertz rays in real time to peer into biological tissue The rays used by airport scanners might have a future in medical imaging.
July 1, 2019
With a light-spinning device inspired by the Japanese art of paper cutting, University of Michigan researchers have detected microscopic twists in the internal structure of plant and animal tissue without harmful X-rays. The approach is the first that can fully rotate terahertz radiation in real time, and it could open new dimensions in medical imaging, […]Read more »
June 28, 2019
Intracerebral hemorrhage, a life-altering type of hemorrhagic stroke, occurs in about 10 to 15 percent of all stroke cases. Individuals who suffer an ICH have a higher rate of disability and death – with about 60 percent of patients surviving at one month – than in other forms of stroke. Once the bleeding stops following […]Read more »
Cancer is smarter than you think: Q&A with Geeta Mehta Decoding the sophisticated inner workings of cancer may help us fight it.
June 26, 2019
Geeta Mehta recently published a paper detailing integrated cancer tissue engineering models, which study cancer not simply as masses of cells but as structured organs with multiple cell types that communicate with each other and interact with the body—much like your lungs or liver. Mehta is the Dow Corning Assistant Professor of Materials Science and […]Read more »
Making the invisible visible: New method opens unexplored realms for liquid biopsies A new approach to RNA sequencing reveals thousands of previously inaccessible RNA fragments in blood plasma that might serve as disease- and organ-specific biomarkers
May 3, 2019
Advancing technology is allowing scientists increasingly to search for tiny signs of cancer and other health issues in samples of patients’ blood and urine. These “liquid biopsies” are less invasive than a traditional biopsy, and can provide information about what’s happening throughout the body instead of just at a single site.Read more »
April 17, 2019
Doctors know they’re the sounds of a problem in the lungs, but it turns out they might be more than symptoms—crackling and wheezing could also be the sounds of a disease progressing, according to a University of Michigan researcher.Read more »
Taking shape: New aligned hydrogel tubes guide spinal tissue regeneration New aligned hydrogel tubes guide spinal tissue regeneration
April 8, 2019
Tissue engineering and regenerative medicine hold the promise of new treatment approaches to spinal cord injuries. Since the human body doesn’t naturally regenerate tissues of the spinal cord, new materials and structures that have similar characteristics to native tissue are needed to realize the potential.Read more »
Recovering reproduction: U-M researchers stimulate follicle growth in mice aimed at creating eggs New approach can boost ovarian follicle survival in mice by up to 75 percent.
April 3, 2019
Leukemia treatments often leave girls infertile, but a procedure developed by researchers at the University of Michigan working with mice is a step toward restoring their ability to be biological mothers.Read more »
Speedy “slingshot” cell movement observed for the first time New findings suggest it might one day be possible to direct healthy cells to advance tissue repair therapies.
March 12, 2019
By slingshotting themselves forward, human cells can travel more than five times faster than previously documented, University of Michigan researchers have found.Read more »
A ‘decathlon’ for antibiotics puts them through more realistic testing Surprise findings could upend the current drug discovery approach for treating one of the most dangerous hospital-borne infections.
January 23, 2019
The University of Michigan’s Sriram Chandrasekaran is using advanced computer simulations to study how different environments affect antibiotic performance.Read more »
December 13, 2018
A new international collaboration is underway, forging deeper connections between U-M BME and Shantou University (STU) in China. The two institutions are working side by side to develop a BME program at STU that will shape the biomedical engineering workforce of tomorrow.Read more »
Has the Olympics changed how it measures false-starts in track? A Q&A with a biomechanics expert who has researched reaction times
August 30, 2018
In 2011, James Ashton-Miller, a Michigan Engineer, helped reveal that Olympic starting-line technology created a different experience for male and female sprinters. It did not accurately detect false starts by women. His latest work provides insights into what may, or may not, have happened since.Read more »
July 3, 2018
The Biomedical Engineering department formally became a joint department of the U-M College of Engineering and the Medical School in 2012, just five years before celebrating its 50th anniversary in 2017. But the spirit and impact of the collaboration that spurred its founding five decades ago continue at an ever-increasing pace today. At the heart […]Read more »
Toward a stem cell model of human nervous system development Human cells could one day show us more about why neural tube birth defects occur and how to prevent them.
June 15, 2018
Human embryonic stem cells can be guided to become the precursor tissue of the central nervous system, research led by the University of Michigan has demonstrated. The new study also reveals the important role of mechanical signals in the development of the human nervous system.Read more »
June 7, 2018
Incubators are common among entrepreneurs to nurture and develop a new product, application, or business idea. Assistant Professor Aileen Huang-Saad is also applying the concept to biomedical engineering practice – and to engineering education – through a novel “instructional incubator” and series of short, experiential courses.Read more »
Findings in mice show pill for breast cancer diagnosis may outperform mammograms A new kind of imaging could distinguish aggressive tumors from benign, preventing unnecessary breast cancer treatments.
May 15, 2018
A new kind of imaging could distinguish aggressive tumors from benign, preventing unnecessary breast cancer treatments.Read more »
‘Nightmare bacteria:’ Michigan Engineers discuss how to combat antibiotic resistance Drug-resistant bugs are on the rise and new approaches are needed.
April 20, 2018
Health officials at the U.S. Centers for Disease Control and Prevention earlier this month said they are seeing rising cases of “nightmare bacteria” that show strong resistance to antibiotics. More than 200 cases were reported in the last year alone, and across every state in the U.S. “Unusual resistance germs—which are resistant to all or […]Read more »
No sponge left behind: tags for surgical equipment A simple, easy-to-implement technology could prevent the debilitating injuries that can occur when organs are damaged by surgical tools left in the body.
April 15, 2018
Items left behind in patients after surgery can have an enormous personal cost when organs and tissues are damaged. Surgical sponges are among the worst offenders – difficult to see in post-surgical X-rays and yet capable of causing holes when the intestines grow around them, for example. These rare cases, estimated around one in 3,000 […]Read more »
April 6, 2018
Assistant Professor Carlos Aguilar has been selected to receive the 2018 3M Non-Tenured Faculty Award from the 3M Corporation. The 3M award recognizes outstanding faculty on the basis of research, experience, teaching and academic leadership. The award was created over twenty-five years ago by 3M’s Technical Community in partnership with the 3Mgives program to invest […]Read more »
A Better Way to Connect Arteries How Coulter’s Newest Licensed Product Is Making Its Way from the Classroom to the Clinic
February 27, 2018
When reconstructive surgeons repair a breast after mastectomy or a severely injured leg after a car accident, they often move tissue harvested from one part of the body to another using microsurgical techniques. A new device developed at U-M and supported by the Coulter Translational Research Partnership Program will make it possible to connect arteries in the transferred tissue to those at the repair site in just minutes with a few easy steps.Read more »
February 16, 2018
Some of the earliest neural engineering work in the field was – pun unintended – conducted at U-M, including the invention of the first silicon neural electrode by Kensall Wise, professor emeritus of BME and Electrical Engineering and Computer Science.
Today a cluster of innovative, accomplished faculty is driving the field forward, working side-by-side with clinicians in the U-M Medical School to focus on translational applications to improve the lives of patients.Read more »
The U-M-Coulter Partnership A pivotal program helps catapult promising biomedical technologies from the lab to the marketplace
January 12, 2018
The 1990s saw the rise of a new term that would reshape biomedical engineering and academic medicine in the years to come — “translational” research.
Driven by funders’ desire to bridge a gap between basic research and clinical application, it encouraged biomedical scientists to more directly impact human health by taking their work “bench to bedside.” In doing so, it suggested that the end-game for academics could just as reasonably be a high-impact journal article as a medical product poised for commercialization.Read more »
December 15, 2017
The work of Assistant Professor Tim Bruns has been recognized with a highly competitive National Science Foundation Faculty Early Career Development (CAREER) Award. The five-year award will fund Bruns’ winning proposal, “Modeling dorsal root ganglia: Electrophysiology of microelectrode recording and stimulation.”Read more »
New funding for high-fidelity nerve mapping research SPARC awarded $1M to a U-M project developing better nerve mapping
December 1, 2017
The National Institutes of Health’s (NIH) Stimulating Peripheral Activity to Relieve Conditions (SPARC) program awarded a University of Michigan project $1 million in funding to develop “highly-compliant microneedle arrays for peripheral nerve mapping.” NIH’s SPARC program seeks to research and develop how nerves interact with organs in order to develop treatments and therapies for diseases, […]Read more »
Kevlar-based artificial cartilage mimics the magic of the real thing In spite of being 80 percent water, cartilage is tough stuff. Now, a synthetic material can pack even more H2O without compromising on strength
December 1, 2017
The unparalleled liquid strength of cartilage, which is about 80 percent water, withstands some of the toughest forces on our bodies. Synthetic materials couldn’t match it – until the “Kevlartilage” developed by researchers at the University of Michigan and Jiangnan University. “We know that we consist mostly of water – all life does – and […]Read more »