The Giessen lab is broadly interested in the chemistry, biology and molecular engineering of microbes. Our current focus lies on understanding and engineering large protein assemblies like microbial protein organelles involved in various aspects of microbial stress resistance and host-microbe interactions within human microbiomes. Our interdisciplinary work utilizes techniques and approaches spanning the fields of biochemistry, structural biology, microbiology, bionanotechnology and synthetic biology. Studying microbial protein organelles will lead to new fundamental insights into the functioning of complex protein machines and illuminate the role spatial control and compartmentalization play in microbial stress resistance, nutrient utilization and pathogenicity. Our research will also lay the foundation for future protein organelle engineering for applications as functional nanomaterials, nanoreactors and programmable nanodevices with the ultimate goal of engineering microbes as living diagnostics, therapeutics and nanofactories.