Dr. Goldstein’s research focused on connective tissue disorders, their prevention or treatment. His large and diverse research program included studies ranging from fracture repair and total joint replacement to investigating the mechanisms associated with inherited or degenerative connective tissue fragility to the development of strategies for tissue regeneration. His primary interests related to the study of biologic or mechanical influences on bone repair and regeneration. His work included basic studies of cell regulators as well as translational studies exploring therapeutic strategies involving cells, biofactors and delivery constructs. Although he no longer has an active laboratory, he continues to serve as a advisor, mentor and collaborator with a number of faculty and on several multidisciplinary centers.  He also continues to advise or interact with other academic centers and several companies.