The Opri laboratory focuses on the exploration of the neurophysiological activity in the basal ganglia-thalamocortical circuits in humans affected by neurological disorders (such as Parkinson’s, Tourette, Essential Tremor, Epilepsy), while investigating how neuromodulation (e.g. Deep Brain Stimulation, cortical stimulation mapping) alters these networks to bring a therapeutic benefit. Our aim is to identify neurological biomarkers that can be leveraged to strengthen the current clinical procedures employed for the treatment of neurological disorders, including advancements in closed-loop neurostimulation. Our goal is to engineer novel methodologies for the automatization and enhancement of clinical procedures in the field of neuromodulation.