Our work is inspired by the interface between materials science and regenerative engineering to address specific problems related to tissue development, repair, and regeneration. By developing mechanically and structurally dynamic biomaterials, microfabrication, and matrix manipulation techniques we aim to recreate complex cell-matrix interactions and model tissue morphogenesis and disease. The ultimate goal is to use these engineered systems to develop and translate more effective therapeutic treatments for diseases such as fibrotic, inflammatory, and congenital disorders. Our work currently focuses on developing engineered lung alveolar organoids, aiming to build models of acute and chronic pulmonary diseases and for personalized medicine.