Computation & Modeling
Objective:
To expedite research by simulating and investigating the behavior of complex systems using mathematics, physics and computer science.
What We Do:
- Develop computer models and simulations
- Research data and identify trends and health patterns
- Model tissue structure and function from the molecular level to whole organ scale to better understand things like the flow of ions in cells, blood in arteries and air in lungs.
Applications:
- Drug Metabolism estimation
- Improvement of recovery timelines
- Determination of infectious disease susceptibility
- Blood flow simulation
Relevant Research from BME Faculty
Dr. Kelly Arnold – Infectious Disease Susceptibility in the Female Reproductive Tract (FRT)
HIV transmission rates vary widely in women, from 1/5 to 1/2000. Previous research indicates the immune microenvironment in the female reproductive tract (a site of transmission) greatly impacts susceptibility. Together with collaborators from Canada and South Africa, the Arnold Lab uses high-throughput mass spectrometry, cytokine, and cytobrush measurements of FRT samples from high-risk women to identify complex rules for immune microenvironments that promote and prevent infection. These rules can generate new hypotheses for systems-level cellular mechanisms involved in HIV susceptibility, multivariate biomarkers for sexually transmitted infections, and aid in future design of preventative microbicides.
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