BME Project 5: Systems biology of stem cell metabolism

Faculty mentor: Sriram Chandrasekaran, Ph.D.
Required skills: MATLAB or Python programming. Basic knowledge of biochemistry, molecular
biology and genetics. Experience working with big data (genomics, transcriptomics) is a plus.
Stem cells holds great promise for regenerative medicine. This project involves
the application of computer models to simulate the metabolic properties of stem cells. The
computer models will be built using genomics, metabolomics and transcriptomics data from
various types of stem cell lines. By understanding the unique metabolic properties of stem cells,
we can design nutrient conditions specific to each cell type. Further, knowledge of these
differences can be used to engineer cells towards a specific cell states.