Dr. Goldstein’s research focuses on connective tissue disorders, their prevention or treatment. His large and diverse research program includes studies ranging from fracture repair and total joint replacement to investigating the mechanisms associated with inherited or degenerative connective tissue fragility to the development of strategies for tissue regeneration. His primary interests relate to the study of biologic or mechanical influences on bone repair and regeneration. His work includes basic studies of cell regulators as well as translational studies exploring therapeutic strategies involving cells, biofactors and delivery constructs. One of the tangible outcomes of the research program has been the development of a novel approach for treating wound and tissue repair using a localized gene therapy delivery strategy that has already been implemented in a successful Phase II clinical trial to treat diabetic ulcers .
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