Mohammad Fallahi-Sichani, Ph.D.

Assistant Professor, Biomedical Engineering

Research in the Fallahi-Sichani Lab combines experimental and computational systems biology approaches to develop a quantitative understanding of oncogenic signaling and therapeutic mechanisms in human tumors. Our ultimate goal is to improve how drugs are used to treat individual cancer patients. We use multiplex biochemical measurement, single-cell analysis, and multi-scale computational modeling to: (i) decode signaling networks that enforce cancer cell fate decision in response to therapeutic and environmental perturbations, (ii) uncover molecular origins of plasticity in cancer cell signaling that underlie variability in therapeutic response, and (iii) develop predictive computational models that guide novel approaches to overcome drug resistance, a major challenge facing cancer therapy.