Explore BME Research


BREADTH. DEPTH. COLLABORATION.

When you have one of the world’s best medical schools and the hub of a major university medical system literally across the street from a top engineering school, amazing things happen.

Michigan BME not only enjoys the facilities and resources of a major research university, but also benefits from a collaborative spirit that proves again and again that the whole is greater than the sum of its parts. We can do what we do because we share a common goal – to make healthcare better for everyone.

RESEARCH AREAS

Biomechanics
Computation & Modeling
Engineering Education
Micro-Nanotechnology & Molecular Engineering
Neural Engineering
Imaging & Biophotonics
Regenerative Medicine

CLINICAL APPLICATIONS

Cancer
Immunology
Cardiovascular

Neurological Disorders

Skeletal / Orthopaedics

TECHNOLOGY

IMAGING

Molecular Imaging
Functional & Physiological

COMPUTATIONAL

Multi-Scale Modeling
Systems Biology

CELLULAR

3D Culture
Biomechanics & Mechanobiology
Cardiovascular
Immuno-Therapeutics
Single Cell Analysis
Gene and Drug Delivery
Cell Transplantations & Therapies

DEVICES

Molecular & Cellular Diagnostics
Histotripsy
Brain Machine Interface
  • Biomechanics

    X

    Calculations may get to the heart of disease

    BME and Vascular Surgery professor Alberto Figueroa is exploring ways to use advanced computing and blood flow models to assess cardiovascular disease.

    Structure, function & systems

    Our early biomechanics advances were inspired by biomedical devices like the Extracorporeal Membrane Oxygenation (ECMO) technology developed by Michigan pediatric surgeon Robert Bartlett in the 1970s. Facilities like the College of Engineering’s Center for Ergonomics help our faculty model the stresses produced in certain situations. But today’s biomechanics research also takes place inside the body, at scales that range from the whole system to the cellular and molecular. Projects include:

    • State-of-the-art blood flow simulation
    • An implantable artificial lung
    • A smartphone-based balance trainer to help people overcome balance problems

    Find a researcher

    Associated Core Faculty

    C. Alberto Figueroa, Ph.D.

    Edward B. Diethrich Associate Professor of Surgery Associate Professor
    Biomedical Engineering

    Ph: (734) 763-8680
    Computational Vascular Biomechanics Lab

    James Grotberg, Ph.D., M.D.

    Professor
    Biomedical Engineering Professor
    Surgery

    Ph: (734) 936-3834
    Fax: (734) 936-1905
    Biofluid Mechanics Research Lab

    Carlos Aguilar, Ph.D.

    Assistant Professor
    Biomedical Engineering

    Ph: 734-764-8557
    NOBEL Lab

    Brian Love, Ph.D.

    Professor
    Biomedical Engineering Professor
    Materials Sciences Professor
    Dentistry

    Ph: (734) 763-2013
    Active and Functional Soft Matter Lab

    Brendon Baker, Ph.D.

    Assistant Professor
    Biomedical Engineering

    Baker Lab

    Susan Brooks, Ph.D.

    Professor
    Biomedical Engineering Professor
    Molecular and Integrative Physiology

    Ph: (734) 936-2147
    Fax: (734) 615-3292

    Rhima Coleman, Ph.D.

    Assistant Professor
    Biomedical Engineering

    Ph: (734) 764-7740
    CHaR Lab

    David Kohn, Ph.D.

    Professor
    Biomedical Engineering Professor
    Dentistry

    Ph: (734) 764-2206
    Fax: (734) 647-2110
    Kohn Lab

    Geeta Mehta, Ph.D.

    Assistant Professor
    Materials Science and Engineering Assistant Professor
    Biomedical Engineering

    Ph: (734) 763-3957
    Fax: (734) 763-4788
    Engineered Cellular Microenvironments (ECM) Lab

    Lonnie Shea, Ph.D.

    William and Valerie Hall Chair
    Biomedical Engineering Professor
    Biomedical Engineering

    Ph: (734) 647-6319
    Fax: (734) 936-1905
    Shea Lab

    Andrew Putnam, Ph.D.

    Robert C. Leland
    Jr. and Donna D. Leland Professor
    Biomedical Engineering and Cardiovascular Medicine

    Ph: (734) 615-1398
    Fax: (734) 647-4834
    CSET Lab

    Jan Stegemann, Ph.D.

    Associate Chair for the Masters Program
    Biomedical Engineering Professor
    Biomedical Engineering

    Ph: (734) 764 8313
    CMITE Lab

  • Computation & Modeling

    X

    Simulation could bring better treatment

    A team led by BME professor James Grotberg developed the first computer model that predicts the flow of liquid medication in human lungs. The technology is providing new insight into the treatment of acute respiratory distress syndrome.

    The healing power of Big Data

    The University of Michigan Health system serves 2.1 million patients a year, generating a tremendous amount of data that can reveal hidden trends and health patterns. With the university’s computational resources, we can model tissue structure and function from the molecular to the whole-organ scale to better understand things like the flow of ions in cells, blood in arteries, and air in the lungs.

    Michigan’s Advanced Research Computing — Technology Services external link provides U-M researchers with advanced computing resources, including:

    • A shared computing cluster, Flux, with more than 16,000 cores
    • A Hadoop cluster for data-science research
    • Cloud computing services
    • Regional and national high performance computing and network resources

    Find a researcher

    Associated Core Faculty

    C. Alberto Figueroa, Ph.D.

    Edward B. Diethrich Associate Professor of Surgery Associate Professor
    Biomedical Engineering

    Ph: (734) 763-8680
    Computational Vascular Biomechanics Lab

    Sriram Chandrasekaran, Ph.D.

    Assistant Professor
    Biomedical Engineering

    Sriram Lab

    Mohammad Fallahi-Sichani, Ph.D.

    Assistant Professor
    Biomedical Engineering

    Ph: (734) 647-2263
    Lab of Cancer Systems Biology and Pharmacology

    Scott Lempka, Ph.D.

    Assistant Professor
    Biomedical Engineering

    Ph: (734) 764-2401
    Neuromodulation Lab

    Mary-Ann Mycek, Ph.D.

    Associate Dean for Graduate Education
    College of Engineering Professor
    Biomedical Engineering

    Ph: (734) 647-6851
    Fax: (734) 647-4834
    Biomedical Optical Diagnostics Laboratory

    Deepak Nagrath, Ph.D.

    Associate Professor
    Biomedical Engineering

    Ph: (734) 764-9889
    Systems Biology of Human Disease  

    David Sept, Ph.D.

    Professor
    Biomedical Engineering

    Ph: (734) 615-9587
    Fax: (734) 647-4834
    Sept Lab

    Lonnie Shea, Ph.D.

    William and Valerie Hall Chair
    Biomedical Engineering Professor
    Biomedical Engineering

    Ph: (734) 647-6319
    Fax: (734) 936-1905
    Shea Lab

  • Engineering Education

    X

    Transforming Engineering Education

    Michigan is committed to bridging the gap between education research and engineering instruction to enhance student learning. Distinct from traditional engineering disciplines and education research, this research lies at the intersection of engineering, education, and the social sciences.

    Influencing the Biomedical Engineers of the Future

    With a deep understanding of engineering, we leverage qualitative and quantitative education research methods to explore innovative means of transforming engineering programs to meet the changing roles of engineers in the global economy. Biomedical engineering graduate students have the option of pursuing their primary research in engineering education while completing one of the BME graduate concentrations to satisfy the master’s degree requirements and the Rackham Certificate in Engineering Education Research to fulfill their PhD requirements.

    Research Focus Areas:

    • Engineering Entrepreneurship and Innovation Education
    • Biomedical Engineering Instructional Change
    • Biomedical Engineering Identity and Interdisciplinarity
    • Strategies for Front-End Design

    Find a researcher

    Associated Core Faculty

    Barry Belmont, Ph.D.

    Lecturer
    Biomedical Engineering

    Ph: (702) 610-1978

    Aileen Huang-Saad, Ph.D., M.B.A.

    Assistant Professor
    Biomedical Engineering Assistant Professor
    Engineering Education

    Ph: (734) 647-9737
    Transforming Engineering Education Lab (TEEL)

  • Micro-Nanotechnology & Molecular Engineering

    X

    Michigan’s combination of facilities, Medical School integration and NIH- supported training program specifically geared toward microfluidics creates a great environment for micro-,nano-, and molecular research.

    The Leaders and Best

    Find a Researcher

    Associated Core Faculty

    Carlos Aguilar, Ph.D.

    Assistant Professor
    Biomedical Engineering

    Ph: 734-764-8557
    NOBEL Lab

    Brendon Baker, Ph.D.

    Assistant Professor
    Biomedical Engineering

    Baker Lab

    Mark Banaszak Holl, Ph.D.

    Professor
    Chemistry Professor
    Macromolecular Science and Engineering Professor
    Biomedical Engineering

    Ph: (734) 763-2283
    Banaszak Holl Group

    Cindy Chestek, Ph.D.

    Assistant Professor
    Biomedical Engineering

    Ph: (734) 763-1759
    Chestek Lab

    Mohammad Fallahi-Sichani, Ph.D.

    Assistant Professor
    Biomedical Engineering

    Ph: (734) 647-2263
    Lab of Cancer Systems Biology and Pharmacology

    Xudong (Sherman) Fan, Ph.D.

    Professor
    Biomedical Engineering

    Ph: (734) 763-1273
    Fax: (734) 647-4834
    Sherman Fan Lab

    David Sept, Ph.D.

    Professor
    Biomedical Engineering

    Ph: (734) 615-9587
    Fax: (734) 647-4834
    Sept Lab

    Geeta Mehta, Ph.D.

    Assistant Professor
    Materials Science and Engineering Assistant Professor
    Biomedical Engineering

    Ph: (734) 763-3957
    Fax: (734) 763-4788
    Engineered Cellular Microenvironments (ECM) Lab

  • Neural Engineering

    X

    Karen Schroeder, BME PhD Student, demonstrates use of a brain machine interface (BMI) system that uses 100 channel arrays implanted the in motor and premotor cortex with the goal of eventually developing clinically viable systems to enable paralyzed individuals to control prosthetic limbs, as well as their own limbs using functional electrical stimulation and assistive exoskeletons.

    Stimulating History

    Michigan has been at the forefront of neurotechnology since the 1970s, when Ken Wise, now a professor emeritus in Electrical Engineering and Computer Science at Michigan, invented the silicon neural probe. Our current cluster of enthusiastic, early-career neural engineering faculty includes affiliates in the Neurology and Neuroscience departments.

    Traditional Mindset

    Find a Researcher

    Associated Core Faculty

    Tim Bruns, Ph.D.

    Assistant Professor
    Biomedical Engineering

    Ph: (734) 647-8727
    Lab Website: http://pneuro.bme.umich.edu LinkedIn Profile

    Cindy Chestek, Ph.D.

    Assistant Professor
    Biomedical Engineering

    Ph: (734) 763-1759
    Chestek Lab

    Scott Lempka, Ph.D.

    Assistant Professor
    Biomedical Engineering

    Ph: (734) 764-2401
    Neuromodulation Lab

    Lonnie Shea, Ph.D.

    William and Valerie Hall Chair
    Biomedical Engineering Professor
    Biomedical Engineering

    Ph: (734) 647-6319
    Fax: (734) 936-1905
    Shea Lab

    James Weiland, Ph.D.

    Professor
    Biomedical Engineering

    BioElectronic Vision Lab

  • Imaging & Biophotonics

    X

    Pushing The Boundaries Of Light And Sound

    Our research in imaging and optics takes ultrasound, MRI, and other imaging technologies in new directions:

    Associated Core Faculty

    Barry Belmont, Ph.D.

    Lecturer
    Biomedical Engineering

    Ph: (702) 610-1978

    Charles Cain, Ph.D.

    Founding Chair
    Biomedical Engineering Professor
    Biomedical Engineering Professor
    Electrical Engineering & Computer Science Richard A. Auhll Professor
    Engineering

    Ph: (734) 764-9589
    Fax: (734) 936-1905
    Histotripsy Group

    Cheri Deng, Ph.D.

    Professor
    Biomedical Engineering

    Ph: (734) 936-2855
    Deng Lab

    Mohammad Fallahi-Sichani, Ph.D.

    Assistant Professor
    Biomedical Engineering

    Ph: (734) 647-2263
    Lab of Cancer Systems Biology and Pharmacology

    Xudong (Sherman) Fan, Ph.D.

    Professor
    Biomedical Engineering

    Ph: (734) 763-1273
    Fax: (734) 647-4834
    Sherman Fan Lab

    Mary-Ann Mycek, Ph.D.

    Associate Dean for Graduate Education
    College of Engineering Professor
    Biomedical Engineering

    Ph: (734) 647-6851
    Fax: (734) 647-4834
    Biomedical Optical Diagnostics Laboratory

    Zhen Xu, Ph.D.

    Associate Chair for Graduate Education
    Biomedical Engineering Associate Professor
    Biomedical Engineering Associate Professor
    Pediatrics

    Ph: (734) 647-4961
    Fax: (734) 939-1905
    http://xulab.bme.umich.edu

  • Regenerative Medicine

    X

    Cancer Decoy

    Researchers in BME and the U-M Comprehensive Cancer Center teamed up to develop a sponge-like device could capture malignant cells and provide early warning before relapse.

    Breath And Strength

    Regenerative medicine leverages not only Michigan’s top Medical and Engineering schools, but also the university’s expertise in basic and biological sciences. No other school with this discipline can claim such across-the-board strength. Researchers across the university collaborate on regenerative medicine to form one of the strongest cohorts anywhere.

    Leaders and Best

    Our faculty include internationally recognized experts in biomaterials, tissue engineering, and regenerative medicine. They work to understand and promote the regeneration of specific tissues, including blood vessels, cartilage, bone, nerve, pancreas and reproductive organs. Our students have opportunities to participate in NIH-sponsored training grants and programs in several fields, including:

    Facilities: Yes, we have them.

    • 3D printing
    • Bioinformatics
    • DNA sequencing
    • Flow cytometry
    • Microscopy
    • Micro- and nano-fabrication
    • Proteomics & peptide synthesis
    • Stem cell production
    • Transgenic animal models

    Find a Researcher

    Associated Core Faculty

    Carlos Aguilar, Ph.D.

    Assistant Professor
    Biomedical Engineering

    Ph: 734-764-8557
    NOBEL Lab

    Lonnie Shea, Ph.D.

    William and Valerie Hall Chair
    Biomedical Engineering Professor
    Biomedical Engineering

    Ph: (734) 647-6319
    Fax: (734) 936-1905
    Shea Lab

    Kelly Arnold, Ph.D.

    Assistant Professor
    Biomedical Engineering

    Arnold Lab

    Brendon Baker, Ph.D.

    Assistant Professor
    Biomedical Engineering

    Baker Lab

    Sriram Chandrasekaran, Ph.D.

    Assistant Professor
    Biomedical Engineering

    Sriram Lab

    Rhima Coleman, Ph.D.

    Assistant Professor
    Biomedical Engineering

    Ph: (734) 764-7740
    CHaR Lab

    David Kohn, Ph.D.

    Professor
    Biomedical Engineering Professor
    Dentistry

    Ph: (734) 764-2206
    Fax: (734) 647-2110
    Kohn Lab

    Geeta Mehta, Ph.D.

    Assistant Professor
    Materials Science and Engineering Assistant Professor
    Biomedical Engineering

    Ph: (734) 763-3957
    Fax: (734) 763-4788
    Engineered Cellular Microenvironments (ECM) Lab

    Mary-Ann Mycek, Ph.D.

    Associate Dean for Graduate Education
    College of Engineering Professor
    Biomedical Engineering

    Ph: (734) 647-6851
    Fax: (734) 647-4834
    Biomedical Optical Diagnostics Laboratory

    Deepak Nagrath, Ph.D.

    Associate Professor
    Biomedical Engineering

    Ph: (734) 764-9889
    Systems Biology of Human Disease  

    Andrew Putnam, Ph.D.

    Robert C. Leland
    Jr. and Donna D. Leland Professor
    Biomedical Engineering and Cardiovascular Medicine

    Ph: (734) 615-1398
    Fax: (734) 647-4834
    CSET Lab

    Ariella Shikanov, Ph.D.

    Assistant Professor
    Biomedical Engineering Assistant Professor
    Macromolecular Science and Engineering

    Ph: (734) 615-3360
    Shikanov Lab

  • Cancer

    X

    Associated core (and key) BME Faculty:

    Challenge:

    Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body.

    Technologies Available/Used:

    • Gene and drug delivery
    • Oncogenic signaling and therapeutic mechanisms
    • Single- cell analysis
    • Multi-Scale computational modeling

    Associated Core Faculty

    Lonnie Shea, Ph.D.

    William and Valerie Hall Chair
    Biomedical Engineering Professor
    Biomedical Engineering

    Ph: (734) 647-6319
    Fax: (734) 936-1905
    Shea Lab

    Mohammad Fallahi-Sichani, Ph.D.

    Assistant Professor
    Biomedical Engineering

    Ph: (734) 647-2263
    Lab of Cancer Systems Biology and Pharmacology

  • Immunology

    X

    Challenge:

    An autoimmune disease, similar to allergies, is a condition resulting from an abnormal immune response to a normal body part. There are at least 80 types of autoimmune diseases, and neraly any body part can be involved.

    Technologies Available/Used:

    • Allogeneic cell transplantation
    • Computational and experimental biology
    • Tissue-engineered constructs
    • Nanoparticle drug delivery methods

    Associated Core Faculty

    Lonnie Shea, Ph.D.

    William and Valerie Hall Chair
    Biomedical Engineering Professor
    Biomedical Engineering

    Ph: (734) 647-6319
    Fax: (734) 936-1905
    Shea Lab

    Kelly Arnold, Ph.D.

    Assistant Professor
    Biomedical Engineering

    Arnold Lab

  • Cardiovascular

    X

    Challenge:

    Cardiovascular disease is a class of diseases that involve the heart or blood vessels, and includes coronary artery diseases such as angina, myocardial infarction (commonly known as a heart attack), stroke, cardiomyopathy, heart arrhythmia, congenital heart disease, and many others, and the underlying mechanisms vary depending on the disease in question.

    Technologies Available/Used:

    • Image- Based simulation of hemodynamics
    • Cardiovascular Integrated Modeling and Simulation
    • Cell and tissue engineering

    Associated Core Faculty

    C. Alberto Figueroa, Ph.D.

    Edward B. Diethrich Associate Professor of Surgery Associate Professor
    Biomedical Engineering

    Ph: (734) 763-8680
    Computational Vascular Biomechanics Lab

    Andrew Putnam, Ph.D.

    Robert C. Leland
    Jr. and Donna D. Leland Professor
    Biomedical Engineering and Cardiovascular Medicine

    Ph: (734) 615-1398
    Fax: (734) 647-4834
    CSET Lab

  • Neurological Disorders

    X

    Challenge:

    A neurological disorder is any disorder of the nervous system. Structural, biomechanical or electrical abnormalities in the brain, spinal cord or other nerves can result in a range of symptoms.

    Technologies Available/Used:

    • Brain Machine interface
    • Neural Probes
    • Sensor arrays
    • Prosthetics

    Associated Core Faculty

    Cindy Chestek, Ph.D.

    Assistant Professor
    Biomedical Engineering

    Ph: (734) 763-1759
    Chestek Lab

    Tim Bruns, Ph.D.

    Assistant Professor
    Biomedical Engineering

    Ph: (734) 647-8727
    Lab Website: http://pneuro.bme.umich.edu LinkedIn Profile

  • Skeletal / Orthopaedics

    X

    Challenge:

    Musculoskeletal Disorders are injuries and disorders that affect the human body’s movement or musculoskeletal system, for example, the muscles, tendons, ligaments, nerves, discs, blood vessels, etc. Common disorders include Carpal Tunnel Syndrome, Tendonitis, and Muscle or Tendon strain.

    Technologies Available/Used:

    • Cartilage & Tissue engineering
    • Muscle 7 Bone regeneration
    • Cellular reprogramming and cell-fate plasticity

    Associated Core Faculty

    Rhima Coleman, Ph.D.

    Assistant Professor
    Biomedical Engineering

    Ph: (734) 764-7740
    CHaR Lab

    Carlos Aguilar, Ph.D.

    Assistant Professor
    Biomedical Engineering

    Ph: 734-764-8557
    NOBEL Lab

    Jan Stegemann, Ph.D.

    Associate Chair for the Masters Program
    Biomedical Engineering Professor
    Biomedical Engineering

    Ph: (734) 764 8313
    CMITE Lab

  • Molecular Imaging

    X

    Objective:

    Molecular Imaging enables the visualization of #D structure and cellular function in living tissues. Quantitative, label free-molecular sensing and diagnostics with minimal perturbation are possible

    Applications:

    • Label-free imaging for biofabrication – personalized medicine
    • Early cancer detection – in vivo diagnosis
    • Drug discovery – assessing therapewutic response ofr precision medicine

    What we do:

    • MRI imaging
    • fMRI

    Associated Core Faculty

    Xueding Wang, Ph.D.

    Associate Professor
    Biomedical Engineering Associate Professor
    Radiology

    Ph: (734) 647-2728
    Fax: (734) 764-8541
    Optical Imaging Lab

  • Functional & Physiological

    X

    Objective:

    Functional magnetic resonance imaging or functional MRI (fMRI) is a functional neuroimaging procedure using MRI technology that measures brain activity by detecting changes associated with blood flow

    What We Do:

    • Ultrasound
    • Photo acoustic
    • Optical imaging

    Applications:

    • Imaging and diagnosis of peripheral artery disease, abdominal aortic aneurysm, cardia function, brain function.
    • Map neural activity of the brain and spinal cord

    Associated Core Faculty

    Douglas Noll

    Ann and Robert H. Lurie Professor
    Biomedical Engineering Professor
    Radiology Co-Director
    fMRI Center

    Ph: (734) 764-9194
    Fax: (734) 936-4218
    http://nollresearch.engin.umich.edu/

    Carlos Aguilar, Ph.D.

    Assistant Professor
    Biomedical Engineering

    Ph: 734-764-8557
    NOBEL Lab

  • Multi-Scale Modeling

    X

    Objective:

    to study processes that take place over multiple physical or temporal scales (e.g. organ vs tissue vs cell vs protein) and that influence each other’s function and performance.

    What we do

    • Molecular simulations
    • Continuum mechanics
    • Agent based modeling

    Applications:

    • Cardiovascular disease research
    • Medical device design and performance evaluation
    • Image-Based non invasive diagnostics
    • Patient-specific planning of complex cardiovascular procedures
    • Better diagnostics, based on relationships between multiple measured factors rather than individual factors
    • New design of mult-combinatorial therapeutics based on systems-level properties
    • Extremely low-cost, low- risk hypothesis-testing of drugs and other therapeutics
    • Agent based modeling

    Associated Core Faculty

    Deepak Nagrath, Ph.D.

    Associate Professor
    Biomedical Engineering

    Ph: (734) 764-9889
    Systems Biology of Human Disease  

    Sriram Chandrasekaran, Ph.D.

    Assistant Professor
    Biomedical Engineering

    Sriram Lab

    David Sept, Ph.D.

    Professor
    Biomedical Engineering

    Ph: (734) 615-9587
    Fax: (734) 647-4834
    Sept Lab

    Lonnie Shea, Ph.D.

    William and Valerie Hall Chair
    Biomedical Engineering Professor
    Biomedical Engineering

    Ph: (734) 647-6319
    Fax: (734) 936-1905
    Shea Lab

  • Systems Biology

    X

    Objective:

    To take a holistic approach to biological research. It is an interdisciplinary field of study that aims to understand how interactions between many simple biological components can give rise to complex behaviors

    What we do:

    • Omics analysis
    • Network modeling
    • Metabolic flux analysis

    Applications:

    • Regenerative medicine
    • Cancer
    • Immune dysfunction

  • 3D Culture

    X

    An artificially created environment in which biological cells are permitted to grow or interact with their surroundings in all three dimensions.

    Applications:

    • Functional tissue models to study development and disease
    • Platforms to investigate how cells interact with chemical, physical, and mechanical aspects of their evironment
    • Tissue analogs to replace diseased or damaged tissue

    Associated Core Faculty

    Jan Stegemann, Ph.D.

    Associate Chair for the Masters Program
    Biomedical Engineering Professor
    Biomedical Engineering

    Ph: (734) 764 8313
    CMITE Lab

    Ariella Shikanov, Ph.D.

    Assistant Professor
    Biomedical Engineering Assistant Professor
    Macromolecular Science and Engineering

    Ph: (734) 615-3360
    Shikanov Lab

    Andrew Putnam, Ph.D.

    Robert C. Leland
    Jr. and Donna D. Leland Professor
    Biomedical Engineering and Cardiovascular Medicine

    Ph: (734) 615-1398
    Fax: (734) 647-4834
    CSET Lab

    Geeta Mehta, Ph.D.

    Assistant Professor
    Materials Science and Engineering Assistant Professor
    Biomedical Engineering

    Ph: (734) 763-3957
    Fax: (734) 763-4788
    Engineered Cellular Microenvironments (ECM) Lab

  • Biomechanics & Mechanobiology

    X

    Objective:

    Focuses on understnading how physical forces and changed in the mechanical properties of cells and tissues contribute to development, physiology, and disease.

    What We Do:

    • Materials with controlled mechanics
    • Mechanical signaling
    • Computational fluid dynamics

    Applications:

    • Refinement of implantable tissues
    • Patient specific computer modeling of flow

  • Cardiovascular

    X

    Objective:

    A subset of BME’s cardiovascular engineering faculty seek to apply engineering tools and analyses to understand the design rules by which the cardiovascular system develops and functions. Others seek to exploit this type of fundamental understanding to create functional vessel replacements across length scales (i,e, from capillaries to large vessels) using cell and material- based strategies.

    Applications:

    • Re-vascularization therapies for treatment of ischemic conditions
    • Wound Healing
    • Vascularization of engineered tissues, especially bone and cardiac muscle

    Associated Core Faculty

    C. Alberto Figueroa, Ph.D.

    Edward B. Diethrich Associate Professor of Surgery Associate Professor
    Biomedical Engineering

    Ph: (734) 763-8680
    Computational Vascular Biomechanics Lab

  • Immuno-Therapeutics

    X

    Objective:

    Immunotherapy is the “treatment of disease by inducing, enhancing, or suppressing an immune response”. Faculty are engaged in applying nano-and biomaterial technologies toward modulating immune responses, as well as developing diagnostic and computational tools for the design of interventions.

    What We Do:

    • Immune actuation
    • Immune tolerance
    • Nano particles
    • Cytokine and chemokine delivery
    • Systems biology of the immune system

    Applications:

    • Cancer (Breast, Prostate, Pancreatic)
    • Allergies (Food, Airway)
    • Pulmonary disease (pulmonary fibrosis, COPD)
    • Autoimmune disease (Multiple Sclerosis Type 1 Diabetes)
    • Infectious Disease (HIV and other STIs, tuberculosis)

    Associated Core Faculty

    Lonnie Shea, Ph.D.

    William and Valerie Hall Chair
    Biomedical Engineering Professor
    Biomedical Engineering

    Ph: (734) 647-6319
    Fax: (734) 936-1905
    Shea Lab

  • Single Cell Analysis

    X

    Objective

    Single-Cell analysis refers to the study of individual cells isolated from tissues in multi-cellular organisms. By studying one cell at a time, the results are certain to stem from that particular cell.

    What We Do:

    • Omics analysis
    • Fluorescence and bio luminescence imaging

    Applications:

    • Cancer
    • Stem cell differentiation
    • Tissue formation
    • Autoimmune disease (Multiple Sclerosis Type 1 Diabetes)
    • Infectious Disease (HIV and other STIs, tuberculosis)

  • Gene and Drug Delivery

    X

    Objective:

    To deliver a pharmaceutical, protein, or nucleic acid to target safely in order to induce a therapeutic effect.

    What We Do:

    • Implantable biomedical scaffolds
    • Injectable nano particles & micro particles
    • Proteins, plasmids, viruses, small molecules

    Applications:

    • Cancer/tumor treatment by targeting cancer cells
    • Regenerative medicine: trophic factors can be made available that can promote the formation of functional tissues
    • Autoimmune diseases/allergies – desensitize a patient to specicfic protiens or factors that induce an aberrant immune response
    • Inflammatory diseases – modulate the trafficking of immune cells that can create inflammation following injury

  • Cell Transplantations & Therapies

    X

    Objective:

    Cell transplantation and therapies seek to create and refine processes for cells to be introduced to the body in a controlled manner to direct function, regrow tissue, and fight disease. We have technologies for engineering the cells, as well as for engineering the environment to maximize engraftment and function.

    What We Do:

    • Cell survival and engraftment
    • Directed differentiation
    • Immune modulation
    • Hydrogels and microporous scaffolds

    Applications:

    • Stem-cell therapies (cancer, diabetes)
    • Spinal Cord injury
    • Fertility preservation
    • Revascularization of tissues and organs
    • Cartilage/bone regeneration and replacement

    Associated Core Faculty

    Lonnie Shea, Ph.D.

    William and Valerie Hall Chair
    Biomedical Engineering Professor
    Biomedical Engineering

    Ph: (734) 647-6319
    Fax: (734) 936-1905
    Shea Lab

  • Molecular & Cellular Diagnostics

    X

    Objective:

    Technologies to analyze biological and chemical markers (genome, proteome, metabolome) in the human body (liquid biopsy, tissue biopsy, breath). Also, technologies for the capture of rare cell types that are causing or related to disease.

    What We Do:

    • Molecular analysis of blood, tissue, breath, and sweat
    • In vivo capture of disease or related cells
    • In vivo probes of diseased tissues

    Applications:

    These techniques are used for early disease detection that can guide therapy or monitor chronic diseases.

    • Chronic disease like diabetes
    • Cancer: early detection of metastic disease
    • Autoimmune disease

    Associated Core Faculty

    Xudong (Sherman) Fan, Ph.D.

    Professor
    Biomedical Engineering

    Ph: (734) 763-1273
    Fax: (734) 647-4834
    Sherman Fan Lab

  • Histotripsy

    X

    Objective:

    Histotripsy controls cavitation to fractionate the target tissue into cellular debris with millimeter accuracy using microsecond, high-pressure ultrasound pulses.

    Applications:

    • Image-Guided non/minimally invasive surgery
    • Cancer/tumor reduction/removal (liver, prostate, kidney, pancreas, etc)
    • Venous thrombosis/ artery plaque removal/ alternate to stent
    • Brain applications (brain tumors, stroke, neural stimulation

    Associated Core Faculty

    Charles Cain, Ph.D.

    Founding Chair
    Biomedical Engineering Professor
    Biomedical Engineering Professor
    Electrical Engineering & Computer Science Richard A. Auhll Professor
    Engineering

    Ph: (734) 764-9589
    Fax: (734) 936-1905
    Histotripsy Group

    Zhen Xu, Ph.D.

    Associate Chair for Graduate Education
    Biomedical Engineering Associate Professor
    Biomedical Engineering Associate Professor
    Pediatrics

    Ph: (734) 647-4961
    Fax: (734) 939-1905
    http://xulab.bme.umich.edu

  • Brain Machine Interface

    X

    Objective:

    Neural Engineering encompasses techniques to interface with and study the nervous system, towards developing devices and treatments to map, assist, augment, and/or repair a wide variety of conditions. Our approaches include placing and modeling the effects of electrodes in or on the brain, retina, spinal cord, and peripheral nerves

    Applications:

    • Controlling Prosthetic Limbs
    • Restoring Vision
    • Reducing or Eliminating Chronic Pain
    • Restoring Bladder Function

    Associated Core Faculty

    Cindy Chestek, Ph.D.

    Assistant Professor
    Biomedical Engineering

    Ph: (734) 763-1759
    Chestek Lab

    Tim Bruns, Ph.D.

    Assistant Professor
    Biomedical Engineering

    Ph: (734) 647-8727
    Lab Website: http://pneuro.bme.umich.edu LinkedIn Profile

    Scott Lempka, Ph.D.

    Assistant Professor
    Biomedical Engineering

    Ph: (734) 764-2401
    Neuromodulation Lab

    James Weiland, Ph.D.

    Professor
    Biomedical Engineering

    BioElectronic Vision Lab

X