Explore BME Research

 

BREADTH. DEPTH. COLLABORATION.

When you have one of the world’s best medical schools and the hub of a major university medical system literally across the street from a top engineering school, amazing things happen.

Michigan BME not only enjoys the facilities and resources of a major research university, but also benefits from a collaborative spirit that proves again and again that the whole is greater than the sum of its parts. We can do what we do because we share a common goal – to make healthcare better for everyone.

Research Areas

BIOMECHANICS & MECHANOBIOLOGY
COMPUTATION & MODELING
ENGINEERING EDUCATION
NEURAL ENGINEERING
MICRO-NANOTECHNOLOGY & MOLECULAR ENGINEERING
IMAGING & BIOPHOTONICS
REGENERATIVE MEDICINE

Clinical Applications

CANCER
IMMUNOLOGY
CARDIOVASCULAR
NEUROLOGICAL DISORDERS
SKELETAL / ORTHOPAEDICS

Technology

Imaging

MOLECULAR IMAGING
FUNCTIONAL & PHYSIOLOGICAL

Computational

MULTI-SCALE MODELING
SYSTEMS BIOLOGY

Cellular

3D CULTURE
BIOMECHANICS & MECHANOBIOLOGY
IMMUNO-THERAPEUTICS
SINGLE CELL ANALYSIS
GENE AND DRUG DELIVERY
CARDIOVASCULAR
CELL TRANSPLANTATIONS AND THERAPIES

Devices

MOLECULAR, CELLULAR, & TISSUE DIAGNOSTICS
HISTOTRIPSY
NEURAL INTERFACES

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Calculations may get to the heart of disease

BME and Vascular Surgery professor Alberto Figueroa is exploring ways to use advanced computing and blood flow models to assess cardiovascular disease.

Structure, function & systems

Our early biomechanics advances were inspired by biomedical devices like the Extracorporeal Membrane Oxygenation (ECMO) technology developed by Michigan pediatric surgeon Robert Bartlett in the 1970s. Facilities like the College of Engineering’s Center for Ergonomics help our faculty model the stresses produced in certain situations. But today’s biomechanics research also takes place inside the body, at scales that range from the whole system to the cellular and molecular. Projects include:
  • State-of-the-art blood flow simulation
  • An implantable artificial lung
  • A smartphone-based balance trainer to help people overcome balance problems

Find a researcher

Lonnie Shea, Ph.D.

William and Valerie Hall Chair
Biomedical Engineering Professor
Biomedical Engineering

Ph: (734) 647-6319
Fax: (734) 936-1905
Shea Lab
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Jan Stegemann, Ph.D.

Associate Chair for the Masters Program
Biomedical Engineering Professor
Biomedical Engineering

Ph: (734) 764 8313
CMITE Lab
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Brendon Baker, Ph.D.

Assistant Professor
Biomedical Engineering

Baker Lab
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Geeta Mehta, Ph.D.

Assistant Professor
Materials Science and Engineering Assistant Professor
Biomedical Engineering

Ph: (734) 763-3957
Fax: (734) 763-4788
Engineered Cellular Microenvironments (ECM) Lab
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Susan Brooks, Ph.D.

Professor
Biomedical Engineering Professor
Molecular and Integrative Physiology

Ph: (734) 936-2147
Fax: (734) 615-3292
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Rhima Coleman, Ph.D.

Assistant Professor
Biomedical Engineering

Ph: (734) 764-7740
CHaR Lab
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C. Alberto Figueroa, Ph.D.

Edward B. Diethrich Professor of Surgery Professor
Biomedical Engineering

Ph: (734) 763-8680
Computational Vascular Biomechanics Lab
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James Grotberg, Ph.D., M.D.

Professor
Biomedical Engineering Professor
Surgery

Ph: (734) 936-3834
Fax: (734) 936-1905
Biofluid Mechanics Research Lab
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David Kohn, Ph.D.

Professor
Biomedical Engineering Professor
Dentistry

Ph: (734) 764-2206
Fax: (734) 647-2110
Kohn Lab
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Brian Love, Ph.D.

Professor
Biomedical Engineering Professor
Materials Sciences Professor
Dentistry

Ph: (734) 763-2013
Active and Functional Soft Matter Lab
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Andrew Putnam, Ph.D.

Robert C. Leland
Jr. and Donna D. Leland Professor
Biomedical Engineering and Cardiovascular Medicine

Ph: (734) 615-1398
Fax: (734) 647-4834
CSET Lab
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Carlos Aguilar, Ph.D.

Assistant Professor
Biomedical Engineering

Ph: 734-764-8557
NOBEL Lab
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Simulation could bring better treatment

A team led by BME professor James Grotberg developed the first computer model that predicts the flow of liquid medication in human lungs. The technology is providing new insight into the treatment of acute respiratory distress syndrome.

The healing power of Big Data

The University of Michigan Health system serves 2.1 million patients a year, generating a tremendous amount of data that can reveal hidden trends and health patterns. With the university’s computational resources, we can model tissue structure and function from the molecular to the whole-organ scale to better understand things like the flow of ions in cells, blood in arteries, and air in the lungs. Michigan’s Advanced Research Computing — Technology Services external link provides U-M researchers with advanced computing resources, including:
  • A shared computing cluster, Flux, with more than 16,000 cores
  • A Hadoop cluster for data-science research
  • Cloud computing services
  • Regional and national high-performance computing and network resources

Find a researcher

Lonnie Shea, Ph.D.

William and Valerie Hall Chair
Biomedical Engineering Professor
Biomedical Engineering

Ph: (734) 647-6319
Fax: (734) 936-1905
Shea Lab
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Kelly Arnold, Ph.D.

Assistant Professor
Biomedical Engineering

Arnold Lab
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Geeta Mehta, Ph.D.

Assistant Professor
Materials Science and Engineering Assistant Professor
Biomedical Engineering

Ph: (734) 763-3957
Fax: (734) 763-4788
Engineered Cellular Microenvironments (ECM) Lab
View Profile

Tim Bruns, Ph.D.

Assistant Professor
Biomedical Engineering

Ph: (734) 647-8727
Lab Website: http://pneuro.bme.umich.edu LinkedIn Profile
View Profile

Rhima Coleman, Ph.D.

Assistant Professor
Biomedical Engineering

Ph: (734) 764-7740
CHaR Lab
View Profile

C. Alberto Figueroa, Ph.D.

Edward B. Diethrich Professor of Surgery Professor
Biomedical Engineering

Ph: (734) 763-8680
Computational Vascular Biomechanics Lab
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James Grotberg, Ph.D., M.D.

Professor
Biomedical Engineering Professor
Surgery

Ph: (734) 936-3834
Fax: (734) 936-1905
Biofluid Mechanics Research Lab
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Mary-Ann Mycek, Ph.D.

Associate Dean for Graduate Education
College of Engineering Professor
Biomedical Engineering

Ph: (734) 647-6851
Fax: (734) 647-4834
Biomedical Optical Diagnostics Laboratory
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David Sept, Ph.D.

Senior Associate Chair
Biomedical Engineering Professor
Biomedical Engineering

Ph: (734) 615-9587
Fax: (734) 647-4834
Sept Lab
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Mohammad Fallahi-Sichani, Ph.D.

Assistant Professor
Biomedical Engineering Assistant Professor
Dermatology

Ph: (734) 647-2263
Lab of Cancer Systems Biology and Pharmacology
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Scott Lempka, Ph.D.

Assistant Professor
Biomedical Engineering Assistant Professor
Anesthesiology

Ph: (734) 764-2401
Neuromodulation Lab
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Deepak Nagrath, Ph.D.

Associate Professor
Biomedical Engineering

Ph: (734) 764-9889
Systems Biology of Human Disease  
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Stimulating History

Michigan has been at the forefront of neurotechnology since the 1970s, when Ken Wise, now a professor emeritus in Electrical Engineering and Computer Science at Michigan, invented the silicon neural probe. Our current cluster of enthusiastic, early-career neural engineering faculty includes affiliates in the Neurology and Neuroscience departments.

Traditional Mindset

Unmatched Resources

Find a Researcher

Lonnie Shea, Ph.D.

William and Valerie Hall Chair
Biomedical Engineering Professor
Biomedical Engineering

Ph: (734) 647-6319
Fax: (734) 936-1905
Shea Lab
View Profile

Tim Bruns, Ph.D.

Assistant Professor
Biomedical Engineering

Ph: (734) 647-8727
Lab Website: http://pneuro.bme.umich.edu LinkedIn Profile
View Profile

Cindy Chestek, Ph.D.

Associate Professor
Biomedical Engineering

Ph: (734) 763-1759
Chestek Lab
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Scott Lempka, Ph.D.

Assistant Professor
Biomedical Engineering Assistant Professor
Anesthesiology

Ph: (734) 764-2401
Neuromodulation Lab
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James Weiland, Ph.D.

Professor
Biomedical Engineering Professor
Ophthalmology and Visual Sciences

Ph: (734) 764-9793
BioElectronic Vision Lab
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X

Transforming Engineering Education

Michigan is committed to bridging the gap between education research and engineering instruction to enhance student learning. Distinct from traditional engineering disciplines and education research, this research lies at the intersection of engineering, education, and the social sciences.

Influencing the Biomedical Engineers of the Future

With a deep understanding of engineering, we leverage qualitative and quantitative education research methods to explore innovative means of transforming engineering programs to meet the changing roles of engineers in the global economy. Biomedical engineering graduate students have the option of pursuing their primary research in engineering education while completing one of the BME graduate concentrations to satisfy the master’s degree requirements and the Rackham Certificate in Engineering Education Research to fulfill their PhD requirements.

Research Focus Areas:

  • Engineering Entrepreneurship and Innovation Education
  • Biomedical Engineering Instructional Change
  • Biomedical Engineering Identity and Interdisciplinarity
  • Strategies for Front-End Design

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X

Michigan's combination of facilities, Medical School integration and NIH- supported training program specifically geared toward microfluidics creates a great environment for micro-,nano-, and molecular research.

The Leaders and Best

Find a Researcher

X

Pushing The Boundaries Of Light And Sound

Our research in imaging and optics takes ultrasound, MRI, and other imaging technologies in new directions:
    • Probing the composition and properties of tissues
    • Treating disease
    • Stimulating growth
 

Michigan is one of the best places in the world for therapeutic ultrasound.

Histotripsy, an extremely high-precision technique that uses ultrasound in non-invasive surgery, was invented here.

Find a Researcher

Charles Cain, Ph.D.

Founding Chair
Biomedical Engineering Professor
Biomedical Engineering Professor
Electrical Engineering & Computer Science Richard A. Auhll Professor
Engineering

Ph: (734) 764-9589
Fax: (734) 936-1905
Histotripsy Group
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Cheri Deng, Ph.D.

Professor
Biomedical Engineering

Ph: (734) 936-2855
Deng Lab
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Xudong (Sherman) Fan, Ph.D.

Professor
Biomedical Engineering

Ph: (734) 763-1273
Fax: (734) 647-4834
Sherman Fan Lab
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Joan Greve, Ph.D.

Assistant Professor
Biomedical Engineering

Greve Lab
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David Kohn, Ph.D.

Professor
Biomedical Engineering Professor
Dentistry

Ph: (734) 764-2206
Fax: (734) 647-2110
Kohn Lab
View Profile

Mary-Ann Mycek, Ph.D.

Associate Dean for Graduate Education
College of Engineering Professor
Biomedical Engineering

Ph: (734) 647-6851
Fax: (734) 647-4834
Biomedical Optical Diagnostics Laboratory
View Profile

Douglas Noll, Ph.D.

Ann and Robert H. Lurie Professor
Biomedical Engineering Professor
Radiology Co-Director
fMRI Center

Ph: (734) 764-9194
Fax: (734) 936-4218
http://nollresearch.engin.umich.edu/
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Xueding Wang, Ph.D.

Professor
Biomedical Engineering Professor
Radiology

Ph: (734) 647-2728
Fax: (734) 764-8541
Optical Imaging Lab
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Zhen Xu, Ph.D.

Associate Chair for Graduate Education
Biomedical Engineering Associate Professor
Biomedical Engineering

Ph: (734) 647-4961
Fax: (734) 939-1905
http://xulab.bme.umich.edu
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Timothy Hall, Ph.D.

Assistant Research Scientist
Biomedical Engineering

Ph: (734) 763-7010
Fax: (734) 936-1905
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Barry Belmont, Ph.D.

Lecturer III
Biomedical Engineering

Ph: (702) 610-1978
The Belmont Lab
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Cancer Decoy

Researchers in BME and the U-M Comprehensive Cancer Center teamed up to develop a sponge-like device could capture malignant cells and provide early warning before relapse.

Breath And Strength

Regenerative medicine leverages not only Michigan’s top Medical and Engineering schools, but also the university’s expertise in basic and biological sciences. No other school with this discipline can claim such across-the-board strength. Researchers across the university collaborate on regenerative medicine to form one of the strongest cohorts anywhere.

Leaders and Best

Our faculty include internationally recognized experts in biomaterials, tissue engineering, and regenerative medicine. They work to understand and promote the regeneration of specific tissues, including blood vessels, cartilage, bone, nerve, pancreas and reproductive organs. Our students have opportunities to participate in NIH-sponsored training grants and programs in several fields, including:

Facilities: Yes, we have them.

  • 3D printing
  • Bioinformatics
  • DNA sequencing
  • Flow cytometry
  • Microscopy
  • Micro- and nano-fabrication
  • Proteomics & peptide synthesis
  • Stem cell production
  • Transgenic animal models

Find a Researcher

Lonnie Shea, Ph.D.

William and Valerie Hall Chair
Biomedical Engineering Professor
Biomedical Engineering

Ph: (734) 647-6319
Fax: (734) 936-1905
Shea Lab
View Profile

Jan Stegemann, Ph.D.

Associate Chair for the Masters Program
Biomedical Engineering Professor
Biomedical Engineering

Ph: (734) 764 8313
CMITE Lab
View Profile

Ariella Shikanov, Ph.D.

Assistant Professor
Biomedical Engineering Assistant Professor
Macromolecular Science and Engineering

Ph: (734) 615-3360
Shikanov Lab
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Kelly Arnold, Ph.D.

Assistant Professor
Biomedical Engineering

Arnold Lab
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Brendon Baker, Ph.D.

Assistant Professor
Biomedical Engineering

Baker Lab
View Profile

Geeta Mehta, Ph.D.

Assistant Professor
Materials Science and Engineering Assistant Professor
Biomedical Engineering

Ph: (734) 763-3957
Fax: (734) 763-4788
Engineered Cellular Microenvironments (ECM) Lab
View Profile

Rhima Coleman, Ph.D.

Assistant Professor
Biomedical Engineering

Ph: (734) 764-7740
CHaR Lab
View Profile

David Kohn, Ph.D.

Professor
Biomedical Engineering Professor
Dentistry

Ph: (734) 764-2206
Fax: (734) 647-2110
Kohn Lab
View Profile

Mary-Ann Mycek, Ph.D.

Associate Dean for Graduate Education
College of Engineering Professor
Biomedical Engineering

Ph: (734) 647-6851
Fax: (734) 647-4834
Biomedical Optical Diagnostics Laboratory
View Profile

Andrew Putnam, Ph.D.

Robert C. Leland
Jr. and Donna D. Leland Professor
Biomedical Engineering and Cardiovascular Medicine

Ph: (734) 615-1398
Fax: (734) 647-4834
CSET Lab
View Profile

Carlos Aguilar, Ph.D.

Assistant Professor
Biomedical Engineering

Ph: 734-764-8557
NOBEL Lab
View Profile

Deepak Nagrath, Ph.D.

Associate Professor
Biomedical Engineering

Ph: (734) 764-9889
Systems Biology of Human Disease  
View Profile

X

Cancer

Challenge:

Cancer is a group of diseases involving abnormal cell growth with the potential to invade or spread to other parts of the body.

Technologies Available / Used at U-M Biomedical Engineering:

  • Gene and drug delivery
  • Oncogenic signaling and therapeutic mechanisms
  • Single-cell analysis
  • Multi-Scale computational modeling

Associated core (and key) BME Faculty:

Lonnie Shea, Ph.D.

William and Valerie Hall Chair
Biomedical Engineering Professor
Biomedical Engineering

Ph: (734) 647-6319
Fax: (734) 936-1905
Shea Lab
View Profile

Ariella Shikanov, Ph.D.

Assistant Professor
Biomedical Engineering Assistant Professor
Macromolecular Science and Engineering

Ph: (734) 615-3360
Shikanov Lab
View Profile

Brendon Baker, Ph.D.

Assistant Professor
Biomedical Engineering

Baker Lab
View Profile

Mohammad Fallahi-Sichani, Ph.D.

Assistant Professor
Biomedical Engineering Assistant Professor
Dermatology

Ph: (734) 647-2263
Lab of Cancer Systems Biology and Pharmacology
View Profile

X

Immunology

Challenge:

An autoimmune disease, similar to allergies, is a condition resulting from an abnormal immune response to a normal body part. There are at least 80 types of autoimmune diseases, and neraly any body part can be involved.

Technologies Available/Used:

  • Allogeneic cell transplantation
  • Computational and experimental biology
  • Tissue-engineered constructs
  • Nanoparticle drug delivery methods

Lonnie Shea, Ph.D.

William and Valerie Hall Chair
Biomedical Engineering Professor
Biomedical Engineering

Ph: (734) 647-6319
Fax: (734) 936-1905
Shea Lab
View Profile

Jan Stegemann, Ph.D.

Associate Chair for the Masters Program
Biomedical Engineering Professor
Biomedical Engineering

Ph: (734) 764 8313
CMITE Lab
View Profile

Kelly Arnold, Ph.D.

Assistant Professor
Biomedical Engineering

Arnold Lab
View Profile

Geeta Mehta, Ph.D.

Assistant Professor
Materials Science and Engineering Assistant Professor
Biomedical Engineering

Ph: (734) 763-3957
Fax: (734) 763-4788
Engineered Cellular Microenvironments (ECM) Lab
View Profile

Mohammad Fallahi-Sichani, Ph.D.

Assistant Professor
Biomedical Engineering Assistant Professor
Dermatology

Ph: (734) 647-2263
Lab of Cancer Systems Biology and Pharmacology
View Profile

X

Cardiovascular

Challenge:

Cardiovascular disease is a class of diseases that involve the heart or blood vessels, and includes coronary artery diseases such as angina, myocardial infarction (commonly known as a heart attack), stroke, cardiomyopathy, heart arrhythmia, congenital heart disease, and many others, and the underlying mechanisms vary depending on the disease in question.

Technologies Available/Used:

  • Image- Based simulation of hemodynamics
  • Cardiovascular Integrated Modeling and Simulation
  • Cell and tissue engineering

Jan Stegemann, Ph.D.

Associate Chair for the Masters Program
Biomedical Engineering Professor
Biomedical Engineering

Ph: (734) 764 8313
CMITE Lab
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Kelly Arnold, Ph.D.

Assistant Professor
Biomedical Engineering

Arnold Lab
View Profile

Brendon Baker, Ph.D.

Assistant Professor
Biomedical Engineering

Baker Lab
View Profile

C. Alberto Figueroa, Ph.D.

Edward B. Diethrich Professor of Surgery Professor
Biomedical Engineering

Ph: (734) 763-8680
Computational Vascular Biomechanics Lab
View Profile

Andrew Putnam, Ph.D.

Robert C. Leland
Jr. and Donna D. Leland Professor
Biomedical Engineering and Cardiovascular Medicine

Ph: (734) 615-1398
Fax: (734) 647-4834
CSET Lab
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X

Neurological Disorders

Challenge:

A neurological disorder is any disorder of the nervous system. Structural, biomechanical or electrical abnormalities in the brain, spinal cord or other nerves can result in a range of symptoms.

Technologies Available/Used:

  • Neural Interfaces
  • Neural Probes
  • Sensor arrays
  • Prosthetics

Tim Bruns, Ph.D.

Assistant Professor
Biomedical Engineering

Ph: (734) 647-8727
Lab Website: http://pneuro.bme.umich.edu LinkedIn Profile
View Profile

Cindy Chestek, Ph.D.

Associate Professor
Biomedical Engineering

Ph: (734) 763-1759
Chestek Lab
View Profile

Scott Lempka, Ph.D.

Assistant Professor
Biomedical Engineering Assistant Professor
Anesthesiology

Ph: (734) 764-2401
Neuromodulation Lab
View Profile

James Weiland, Ph.D.

Professor
Biomedical Engineering Professor
Ophthalmology and Visual Sciences

Ph: (734) 764-9793
BioElectronic Vision Lab
View Profile

X

Skeletal / Orthopaedics

Challenge:

Musculoskeletal Disorders are injuries and disorders that affect the human body's movement or musculoskeletal system, for example, the muscles, tendons, ligaments, nerves, discs, blood vessels, etc. Common disorders include Carpal Tunnel Syndrome, Tendonitis, and Muscle or Tendon strain.

Technologies Available/Used:

  • Cartilage & Tissue engineering
  • Muscle 7 Bone regeneration
  • Cellular reprogramming and cell-fate plasticity

Jan Stegemann, Ph.D.

Associate Chair for the Masters Program
Biomedical Engineering Professor
Biomedical Engineering

Ph: (734) 764 8313
CMITE Lab
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Rhima Coleman, Ph.D.

Assistant Professor
Biomedical Engineering

Ph: (734) 764-7740
CHaR Lab
View Profile

David Kohn, Ph.D.

Professor
Biomedical Engineering Professor
Dentistry

Ph: (734) 764-2206
Fax: (734) 647-2110
Kohn Lab
View Profile

Mary-Ann Mycek, Ph.D.

Associate Dean for Graduate Education
College of Engineering Professor
Biomedical Engineering

Ph: (734) 647-6851
Fax: (734) 647-4834
Biomedical Optical Diagnostics Laboratory
View Profile

Carlos Aguilar, Ph.D.

Assistant Professor
Biomedical Engineering

Ph: 734-764-8557
NOBEL Lab
View Profile

X

Molecular Imaging

Objective:

Molecular Imaging enables the visualization of #D structure and cellular function in living tissues. Quantitative, label free-molecular sensing and diagnostics with minimal perturbation are possible

Applications:

  • Label-free imaging for biofabrication - personalized medicine
  • Early cancer detection - in vivo diagnosis
  • Drug discovery - assessing therapewutic response ofr precision medicine

What we do:

  • MRI imaging
  • fMRI

Ariella Shikanov, Ph.D.

Assistant Professor
Biomedical Engineering Assistant Professor
Macromolecular Science and Engineering

Ph: (734) 615-3360
Shikanov Lab
View Profile

Xueding Wang, Ph.D.

Professor
Biomedical Engineering Professor
Radiology

Ph: (734) 647-2728
Fax: (734) 764-8541
Optical Imaging Lab
View Profile

X

Functional & Physiological

Objective:

Functional magnetic resonance imaging or functional MRI (fMRI) is a functional neuroimaging procedure using MRI technology that measures brain activity by detecting changes associated with blood flow

What We Do:

  • Ultrasound
  • Photo acoustic
  • Optical imaging

Applications:

  • Imaging and diagnosis of peripheral artery disease, abdominal aortic aneurysm, cardia function, brain function.
  • Map neural activity of the brain and spinal cord

Jan Stegemann, Ph.D.

Associate Chair for the Masters Program
Biomedical Engineering Professor
Biomedical Engineering

Ph: (734) 764 8313
CMITE Lab
View Profile

Ariella Shikanov, Ph.D.

Assistant Professor
Biomedical Engineering Assistant Professor
Macromolecular Science and Engineering

Ph: (734) 615-3360
Shikanov Lab
View Profile

C. Alberto Figueroa, Ph.D.

Edward B. Diethrich Professor of Surgery Professor
Biomedical Engineering

Ph: (734) 763-8680
Computational Vascular Biomechanics Lab
View Profile

David Kohn, Ph.D.

Professor
Biomedical Engineering Professor
Dentistry

Ph: (734) 764-2206
Fax: (734) 647-2110
Kohn Lab
View Profile

Mary-Ann Mycek, Ph.D.

Associate Dean for Graduate Education
College of Engineering Professor
Biomedical Engineering

Ph: (734) 647-6851
Fax: (734) 647-4834
Biomedical Optical Diagnostics Laboratory
View Profile

Douglas Noll, Ph.D.

Ann and Robert H. Lurie Professor
Biomedical Engineering Professor
Radiology Co-Director
fMRI Center

Ph: (734) 764-9194
Fax: (734) 936-4218
http://nollresearch.engin.umich.edu/
View Profile

Carlos Aguilar, Ph.D.

Assistant Professor
Biomedical Engineering

Ph: 734-764-8557
NOBEL Lab
View Profile

X

Multi-Scale Modeling

Objective:

to study processes that take place over multiple physical or temporal scales (e.g. organ vs tissue vs cell vs protein) and that influence each other's function and performance.

What we do

  • Molecular simulations
  • Continuum mechanics
  • Agent based modeling

Applications:

  • Cardiovascular disease research
  • Medical device design and performance evaluation
  • Image-Based non invasive diagnostics
  • Patient-specific planning of complex cardiovascular procedures
  • Better diagnostics, based on relationships between multiple measured factors rather than individual factors
  • New design of mult-combinatorial therapeutics based on systems-level properties
  • Extremely low-cost, low- risk hypothesis-testing of drugs and other therapeutics
  • Agent based modeling

Lonnie Shea, Ph.D.

William and Valerie Hall Chair
Biomedical Engineering Professor
Biomedical Engineering

Ph: (734) 647-6319
Fax: (734) 936-1905
Shea Lab
View Profile

Ariella Shikanov, Ph.D.

Assistant Professor
Biomedical Engineering Assistant Professor
Macromolecular Science and Engineering

Ph: (734) 615-3360
Shikanov Lab
View Profile

Kelly Arnold, Ph.D.

Assistant Professor
Biomedical Engineering

Arnold Lab
View Profile

Geeta Mehta, Ph.D.

Assistant Professor
Materials Science and Engineering Assistant Professor
Biomedical Engineering

Ph: (734) 763-3957
Fax: (734) 763-4788
Engineered Cellular Microenvironments (ECM) Lab
View Profile

C. Alberto Figueroa, Ph.D.

Edward B. Diethrich Professor of Surgery Professor
Biomedical Engineering

Ph: (734) 763-8680
Computational Vascular Biomechanics Lab
View Profile

James Grotberg, Ph.D., M.D.

Professor
Biomedical Engineering Professor
Surgery

Ph: (734) 936-3834
Fax: (734) 936-1905
Biofluid Mechanics Research Lab
View Profile

David Sept, Ph.D.

Senior Associate Chair
Biomedical Engineering Professor
Biomedical Engineering

Ph: (734) 615-9587
Fax: (734) 647-4834
Sept Lab
View Profile

Mohammad Fallahi-Sichani, Ph.D.

Assistant Professor
Biomedical Engineering Assistant Professor
Dermatology

Ph: (734) 647-2263
Lab of Cancer Systems Biology and Pharmacology
View Profile

Scott Lempka, Ph.D.

Assistant Professor
Biomedical Engineering Assistant Professor
Anesthesiology

Ph: (734) 764-2401
Neuromodulation Lab
View Profile

Deepak Nagrath, Ph.D.

Associate Professor
Biomedical Engineering

Ph: (734) 764-9889
Systems Biology of Human Disease  
View Profile

X

Systems Biology

Objective:

To take a holistic approach to biological research. It is an interdisciplinary field of study that aims to understand how interactions between many simple biological components can give rise to complex behaviors

What we do:

  • Omics analysis
  • Network modeling
  • Metabolic flux analysis

Applications:

  • Regenerative medicine
  • Cancer
  • Immune dysfunction

Ariella Shikanov, Ph.D.

Assistant Professor
Biomedical Engineering Assistant Professor
Macromolecular Science and Engineering

Ph: (734) 615-3360
Shikanov Lab
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Kelly Arnold, Ph.D.

Assistant Professor
Biomedical Engineering

Arnold Lab
View Profile

Carlos Aguilar, Ph.D.

Assistant Professor
Biomedical Engineering

Ph: 734-764-8557
NOBEL Lab
View Profile

Mohammad Fallahi-Sichani, Ph.D.

Assistant Professor
Biomedical Engineering Assistant Professor
Dermatology

Ph: (734) 647-2263
Lab of Cancer Systems Biology and Pharmacology
View Profile

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3D Culture

An artificially created environment in which biological cells are permitted to grow or interact with their surroundings in all three dimensions.

Applications:

  • Functional tissue models to study development and disease
  • Platforms to investigate how cells interact with chemical, physical, and mechanical aspects of their evironment
  • Tissue analogs to replace diseased or damaged tissue

Jan Stegemann, Ph.D.

Associate Chair for the Masters Program
Biomedical Engineering Professor
Biomedical Engineering

Ph: (734) 764 8313
CMITE Lab
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Ariella Shikanov, Ph.D.

Assistant Professor
Biomedical Engineering Assistant Professor
Macromolecular Science and Engineering

Ph: (734) 615-3360
Shikanov Lab
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Brendon Baker, Ph.D.

Assistant Professor
Biomedical Engineering

Baker Lab
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Geeta Mehta, Ph.D.

Assistant Professor
Materials Science and Engineering Assistant Professor
Biomedical Engineering

Ph: (734) 763-3957
Fax: (734) 763-4788
Engineered Cellular Microenvironments (ECM) Lab
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Rhima Coleman, Ph.D.

Assistant Professor
Biomedical Engineering

Ph: (734) 764-7740
CHaR Lab
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David Kohn, Ph.D.

Professor
Biomedical Engineering Professor
Dentistry

Ph: (734) 764-2206
Fax: (734) 647-2110
Kohn Lab
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Andrew Putnam, Ph.D.

Robert C. Leland
Jr. and Donna D. Leland Professor
Biomedical Engineering and Cardiovascular Medicine

Ph: (734) 615-1398
Fax: (734) 647-4834
CSET Lab
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Biomechanics & Mechanobiology

Objective:

Focuses on understanding how physical forces and changed in the mechanical properties of cells and tissues contribute to development, physiology, and disease.

What We Do:

  • Materials with controlled mechanics
  • Mechanical signaling
  • Computational fluid dynamics

Applications:

  • Refinement of implantable tissues
  • Patient specific computer modeling of flow

Jan Stegemann, Ph.D.

Associate Chair for the Masters Program
Biomedical Engineering Professor
Biomedical Engineering

Ph: (734) 764 8313
CMITE Lab
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Brendon Baker, Ph.D.

Assistant Professor
Biomedical Engineering

Baker Lab
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Geeta Mehta, Ph.D.

Assistant Professor
Materials Science and Engineering Assistant Professor
Biomedical Engineering

Ph: (734) 763-3957
Fax: (734) 763-4788
Engineered Cellular Microenvironments (ECM) Lab
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Rhima Coleman, Ph.D.

Assistant Professor
Biomedical Engineering

Ph: (734) 764-7740
CHaR Lab
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James Grotberg, Ph.D., M.D.

Professor
Biomedical Engineering Professor
Surgery

Ph: (734) 936-3834
Fax: (734) 936-1905
Biofluid Mechanics Research Lab
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David Kohn, Ph.D.

Professor
Biomedical Engineering Professor
Dentistry

Ph: (734) 764-2206
Fax: (734) 647-2110
Kohn Lab
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Andrew Putnam, Ph.D.

Robert C. Leland
Jr. and Donna D. Leland Professor
Biomedical Engineering and Cardiovascular Medicine

Ph: (734) 615-1398
Fax: (734) 647-4834
CSET Lab
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Carlos Aguilar, Ph.D.

Assistant Professor
Biomedical Engineering

Ph: 734-764-8557
NOBEL Lab
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Immuno-Therapeutics

Objective:

Immunotherapy is the "treatment of disease by inducing, enhancing, or suppressing an immune response". Faculty are engaged in applying nano-and biomaterial technologies toward modulating immune responses, as well as developing diagnostic and computational tools for the design of interventions.

What We Do:

  • Immune actuation
  • Immune tolerance
  • Nano particles
  • Cytokine and chemokine delivery
  • Systems biology of the immune system

Applications:

  • Cancer (Breast, Prostate, Pancreatic)
  • Allergies (Food, Airway)
  • Pulmonary disease (pulmonary fibrosis, COPD)
  • Autoimmune disease (Multiple Sclerosis Type 1 Diabetes)
  • Infectious Disease (HIV and other STIs, tuberculosis)

Lonnie Shea, Ph.D.

William and Valerie Hall Chair
Biomedical Engineering Professor
Biomedical Engineering

Ph: (734) 647-6319
Fax: (734) 936-1905
Shea Lab
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Jan Stegemann, Ph.D.

Associate Chair for the Masters Program
Biomedical Engineering Professor
Biomedical Engineering

Ph: (734) 764 8313
CMITE Lab
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Ariella Shikanov, Ph.D.

Assistant Professor
Biomedical Engineering Assistant Professor
Macromolecular Science and Engineering

Ph: (734) 615-3360
Shikanov Lab
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Kelly Arnold, Ph.D.

Assistant Professor
Biomedical Engineering

Arnold Lab
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Brendon Baker, Ph.D.

Assistant Professor
Biomedical Engineering

Baker Lab
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Geeta Mehta, Ph.D.

Assistant Professor
Materials Science and Engineering Assistant Professor
Biomedical Engineering

Ph: (734) 763-3957
Fax: (734) 763-4788
Engineered Cellular Microenvironments (ECM) Lab
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Andrew Putnam, Ph.D.

Robert C. Leland
Jr. and Donna D. Leland Professor
Biomedical Engineering and Cardiovascular Medicine

Ph: (734) 615-1398
Fax: (734) 647-4834
CSET Lab
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Mohammad Fallahi-Sichani, Ph.D.

Assistant Professor
Biomedical Engineering Assistant Professor
Dermatology

Ph: (734) 647-2263
Lab of Cancer Systems Biology and Pharmacology
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Single Cell Analysis

Objective

Single-Cell analysis refers to the study of individual cells isolated from tissues in multi-cellular organisms. By studying one cell at a time, the results are certain to stem from that particular cell.

What We Do:

  • Omics analysis
  • Fluorescence and bio luminescence imaging

Applications:

  • Cancer
  • Stem cell differentiation
  • Tissue formation
  • Autoimmune disease (Multiple Sclerosis Type 1 Diabetes)
  • Infectious Disease (HIV and other STIs, tuberculosis)

Ariella Shikanov, Ph.D.

Assistant Professor
Biomedical Engineering Assistant Professor
Macromolecular Science and Engineering

Ph: (734) 615-3360
Shikanov Lab
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Brendon Baker, Ph.D.

Assistant Professor
Biomedical Engineering

Baker Lab
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Geeta Mehta, Ph.D.

Assistant Professor
Materials Science and Engineering Assistant Professor
Biomedical Engineering

Ph: (734) 763-3957
Fax: (734) 763-4788
Engineered Cellular Microenvironments (ECM) Lab
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Carlos Aguilar, Ph.D.

Assistant Professor
Biomedical Engineering

Ph: 734-764-8557
NOBEL Lab
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Mohammad Fallahi-Sichani, Ph.D.

Assistant Professor
Biomedical Engineering Assistant Professor
Dermatology

Ph: (734) 647-2263
Lab of Cancer Systems Biology and Pharmacology
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Gene and Drug Delivery

Objective:

To deliver a pharmaceutical, protein, or nucleic acid to target safely in order to induce a therapeutic effect.

What We Do:

  • Implantable biomedical scaffolds
  • Injectable nano particles & micro particles
  • Proteins, plasmids, viruses, small molecules

Applications:

  • Cancer/tumor treatment by targeting cancer cells
  • Regenerative medicine: trophic factors can be made available that can promote the formation of functional tissues
  • Autoimmune diseases/allergies - desensitize a patient to specicfic protiens or factors that induce an aberrant immune response
  • Inflammatory diseases - modulate the trafficking of immune cells that can create inflammation following injury

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Cell Transplantations & Therapies

Objective:

Cell transplantation and therapies seek to create and refine processes for cells to be introduced to the body in a controlled manner to direct function, regrow tissue, and fight disease. We have technologies for engineering the cells, as well as for engineering the environment to maximize engraftment and function.

What We Do:

  • Cell survival and engraftment
  • Directed differentiation
  • Immune modulation
  • Hydrogels and microporous scaffolds

Applications:

  • Stem-cell therapies (cancer, diabetes)
  • Spinal Cord injury
  • Fertility preservation
  • Revascularization of tissues and organs
  • Cartilage/bone regeneration and replacement

Lonnie Shea, Ph.D.

William and Valerie Hall Chair
Biomedical Engineering Professor
Biomedical Engineering

Ph: (734) 647-6319
Fax: (734) 936-1905
Shea Lab
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Jan Stegemann, Ph.D.

Associate Chair for the Masters Program
Biomedical Engineering Professor
Biomedical Engineering

Ph: (734) 764 8313
CMITE Lab
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Ariella Shikanov, Ph.D.

Assistant Professor
Biomedical Engineering Assistant Professor
Macromolecular Science and Engineering

Ph: (734) 615-3360
Shikanov Lab
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Kelly Arnold, Ph.D.

Assistant Professor
Biomedical Engineering

Arnold Lab
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Brendon Baker, Ph.D.

Assistant Professor
Biomedical Engineering

Baker Lab
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Geeta Mehta, Ph.D.

Assistant Professor
Materials Science and Engineering Assistant Professor
Biomedical Engineering

Ph: (734) 763-3957
Fax: (734) 763-4788
Engineered Cellular Microenvironments (ECM) Lab
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Rhima Coleman, Ph.D.

Assistant Professor
Biomedical Engineering

Ph: (734) 764-7740
CHaR Lab
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David Kohn, Ph.D.

Professor
Biomedical Engineering Professor
Dentistry

Ph: (734) 764-2206
Fax: (734) 647-2110
Kohn Lab
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Andrew Putnam, Ph.D.

Robert C. Leland
Jr. and Donna D. Leland Professor
Biomedical Engineering and Cardiovascular Medicine

Ph: (734) 615-1398
Fax: (734) 647-4834
CSET Lab
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Carlos Aguilar, Ph.D.

Assistant Professor
Biomedical Engineering

Ph: 734-764-8557
NOBEL Lab
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Mohammad Fallahi-Sichani, Ph.D.

Assistant Professor
Biomedical Engineering Assistant Professor
Dermatology

Ph: (734) 647-2263
Lab of Cancer Systems Biology and Pharmacology
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Cardiovascular

Objective:

A subset of BME's cardiovascular engineering faculty seek to apply engineering tools and analyses to understand the design rules by which the cardiovascular system develops and functions. Others seek to exploit this type of fundamental understanding to create functional vessel replacements across length scales (i,e, from capillaries to large vessels) using cell and material- based strategies.

Applications:

  • Re-vascularization therapies for treatment of ischemic conditions
  • Wound Healing
  • Vascularization of engineered tissues, especially bone and cardiac muscle

C. Alberto Figueroa, Ph.D.

Edward B. Diethrich Professor of Surgery Professor
Biomedical Engineering

Ph: (734) 763-8680
Computational Vascular Biomechanics Lab
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Molecular, Cellular Diagnostics, and Tissue Diagnostics

Objective:

Technologies to analyze biological and chemical markers (genome, proteome, metabolome) in the human body (liquid biopsy, tissue biopsy, breath). Also, technologies for the capture of rare cell types that are causing or related to disease.

What We Do:

  • Molecular analysis of blood, tissue, breath, and sweat
  • In vivo capture of disease or related cells
  • In vivo probes of diseased tissues

Applications:

These techniques are used for early disease detection that can guide therapy or monitor chronic diseases.
  • Chronic disease like diabetes
  • Cancer: early detection of metastic disease
  • Autoimmune disease

Geeta Mehta, Ph.D.

Assistant Professor
Materials Science and Engineering Assistant Professor
Biomedical Engineering

Ph: (734) 763-3957
Fax: (734) 763-4788
Engineered Cellular Microenvironments (ECM) Lab
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Xudong (Sherman) Fan, Ph.D.

Professor
Biomedical Engineering

Ph: (734) 763-1273
Fax: (734) 647-4834
Sherman Fan Lab
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Histotripsy

Objective:

Histotripsy controls cavitation to fractionate the target tissue into cellular debris with millimeter accuracy using microsecond, high-pressure ultrasound pulses.

Applications:

  • Image-Guided non/minimally invasive surgery
  • Cancer/tumor reduction/removal (liver, prostate, kidney, pancreas, etc)
  • Venous thrombosis/ artery plaque removal/ alternate to stent
  • Brain applications (brain tumors, stroke, neural stimulation

Charles Cain, Ph.D.

Founding Chair
Biomedical Engineering Professor
Biomedical Engineering Professor
Electrical Engineering & Computer Science Richard A. Auhll Professor
Engineering

Ph: (734) 764-9589
Fax: (734) 936-1905
Histotripsy Group
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Zhen Xu, Ph.D.

Associate Chair for Graduate Education
Biomedical Engineering Associate Professor
Biomedical Engineering

Ph: (734) 647-4961
Fax: (734) 939-1905
http://xulab.bme.umich.edu
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Timothy Hall, Ph.D.

Assistant Research Scientist
Biomedical Engineering

Ph: (734) 763-7010
Fax: (734) 936-1905
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Neural Interfaces

Objective:

Neural Engineering encompasses techniques to interface with and study the nervous system, towards developing devices and treatments to map, assist, augment, and/or repair a wide variety of conditions. Our approaches include placing and modeling the effects of electrodes in or on the brain, retina, spinal cord, and peripheral nerves

Applications:

  • Controlling Prosthetic Limbs
  • Restoring Vision
  • Reducing or Eliminating Chronic Pain
  • Restoring Bladder Function

Tim Bruns, Ph.D.

Assistant Professor
Biomedical Engineering

Ph: (734) 647-8727
Lab Website: http://pneuro.bme.umich.edu LinkedIn Profile
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Cindy Chestek, Ph.D.

Associate Professor
Biomedical Engineering

Ph: (734) 763-1759
Chestek Lab
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Scott Lempka, Ph.D.

Assistant Professor
Biomedical Engineering Assistant Professor
Anesthesiology

Ph: (734) 764-2401
Neuromodulation Lab
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James Weiland, Ph.D.

Professor
Biomedical Engineering Professor
Ophthalmology and Visual Sciences

Ph: (734) 764-9793
BioElectronic Vision Lab
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